�ARYx Therapeutics, Inc., (NASDAQ:ARYX), a biopharmaceutical company, announced the results of a Phase 2b clinical trial testing the safety and efficacy of its prokinetic agent, ATI-7505, in patients with chronic idiopathic impairment. The clinical trial, conducted by Procter and Gamble Pharmaceuticals (P&G), was designed to enrol 400 patients evaluating quatern doses of the agent compared to placebo. As announced last month, the study was terminated other after exclusively 214 patients had been enrolled, as a solution of the termination of the collaboration between ARYx and P&G.
"In nastiness of the early expiry of the study, ATI-7505 achieved statistical significance at the study's primary terminus in the 80 mg twice daily dose. In addition, all doses tested demonstrated a clinically meaningful increase in spontaneous intestine movements over baseline compared to placebo after unitary week of treatment," said Dr. Paul Goddard, Chief Executive Officer and Chairman of ARYx. "From a tolerability linear perspective, ATI-7505 improved patients' ability to see spontaneous gut movements with virtually no reports of diarrhea or nausea from the patients in this trial."
The clinical trial was a Phase 2b, randomized, placebo-controlled study of ATI-7505 in patients with chronic idiopathic constipation conducted at 42 trial sites in 5 countries. Patients were treated for 4 weeks and the primary efficacy end point was the improvement in the tote up number of spontaneous gut movements (SBM) during the first 7 days after randomization compared to placebo. Patients were randomized to either placebo or doses of ATI-7505 of 20 mg twice a mean solar day (bid), 40 mg press, 80 mg bid, or 120 mg bid. Randomization was balanced amongst all treatment blazonry. SBM was defined as a gut movement occurring without the need for a laxative or enema within the preceding 24 hours. Safety assessments were conducted on every patient enrolled.
Utilizing the original statistical analysis plan for the total study, statistical significance (p=0.0031) was achieved at the 80 mg tender dose with an increase of a mean of 3.32 SBMs in the first week compared to service line. In the placebo radical, this increment was only 0.31 SBMs. A preliminary analysis of the overall answerer rate indicates ATI-7505 kept up its prescribed effect over the full 4-week treatment period. In addition, time-to-first SBM using a Kaplan-Meier analysis suggests that many patients on ATI-7505, unlike placebo, sustain their first SBM following the number one dose of the drug and this effect was observed at all doses tested. The 80 mg bid dosage was very well tolerated and in that respect were no reports of diarrhea, nausea or emesis.
"As sweet as these results ar, particularly when coupled to the lately announced results of the Thorough QT study conducted on ATI-7505, ARYx remains committed to focusing our primary efforts on producing the clinical trial results necessary to partner our other deuce Phase 2 clinical candidates, our oral anticoagulant agent ATI-5923 and our oral anti-arrhythmic agent ATI-2042," continued Dr. Goddard. "While we will seek a new development mate for ATI-7505, our partnering efforts will remain focussed on maximizing the value of ATI-5923 and ATI-2042. In the meantime, we will carry on to analyse the results of this chronic impairment study so they whitethorn be presented to potential partners along with the rest of the material data supporting ATI-7505."
About ARYx Therapeutics, Inc.
ARYx Therapeutics is a biopharmaceutical company focussed on development a portfolio of internally discovered products designed to eliminate known safety issues associated with well-established, commercially successful drugs. ARYx uses its RetroMetabolic Drug Design� technology to design structurally unique molecules that retain the efficacy of these original drugs but are metabolized through a potentially safer pathway to avoid specific untoward side personal effects associated with these compounds. ARYx currently has quaternity products in clinical trials: an oral anticoagulant agent for patients at peril for the formation of dangerous blood clots, ATI-5923; an oral anti-arrhythmic agent for the treatment of atrial fibrillation, ATI-2042; a prokinetic agent for the treatment of various gastrointestinal disorders, ATI-7505; and, an agent for the treatment of schizophrenia and other psychiatric disorders, ATI-9242. Please visit our web site at wWW.aryx.com for extra information.
About ATI-7505
ATI-7505 is our product designed to normalize upper and lower gI motility to treat diverse GI disorders. A potent agonist of 5-HT4 receptors which survive throughout the GI tract regulating stomachic emptying and the motility of solid food through the intestines, ATI-7505 is engineered to maintain the efficaciousness of cisapride, a do drugs that reached peak sales of $1.0 gazillion a year prior to being recluse from the market in 2000 due to severe cardiac toxicities. However, unlike cisapride, ATI-7505 is non dependent upon a rate-limiting cytochrome P450 enzyme in the liver for metamorphosis and hence is designed to avoid the progress of drug levels associated with cisapride's toxicities. In addition, ATI-7505 is more than selective than cisapride having minimal activity on the hERG television channel in the heart and virtually no activity at the 5-HT3 or other serotonergic receptors. To rein.
ARYx Therapeutics, Inc.
More info
Wednesday, 3 September 2008
Wednesday, 6 August 2008
Dave Stewart and The Spiritual Cowboys
Artist: Dave Stewart and The Spiritual Cowboys
Genre(s):
Jazz
Discography:
Dave Stewart and The Spiritual Cowboys
Year: 1990
Tracks: 14
Bjork Pulls Out Of Wild In The Country Festival
Friday, 27 June 2008
Gary Dourdan: The Fat Man Cometh
Former "CSI" douche Gary Dourdan emerged thicker in L.A. on Wednesday, after copping to drug charges and hitting up rehab last month.Unfortunately, with his scarf-tie thingy, necklaces, rings, cuff, bracelet, watch and wallet chain, Dourdan is now guilty of possessing way too many damn accessories. Just say no, Gary.
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Thursday, 19 June 2008
DJ Sakin and Friends
Artist: DJ Sakin and Friends
Genre(s):
Trance
Pop
Dance
Discography:
Protect Your Mind
Year: 2002
Tracks: 4
Walk on Fire
Year: 2001
Tracks: 15
Dragonfly
Year: 1999
Tracks: 5
Nomansland
Year: 1998
Tracks: 3
Hotstylez
Friday, 13 June 2008
Temperatures Plummet Ahead Of Isle Of Wight Festival
A mixture of rain and sunny spells will greet festivalgoers heading to the Isle of Wight Festival this weekend.
Forecasters are predicting heavy showers tomorrow (June 13th), the first day of the festival, and a maximum temperature of 17 decrees Celsius.
Although the cool temperatures will remain, conditions are expected to brighten over the course of the weekend with sunny spells breaking up the rain showers.
As previously reported, this years Isle of Wight festival will feature headlining performances from Kaiser Chiefs, The Police and Sex Pistols.
Tickets for the festival have sold out. For all the latest information on all this year's festivals, check out our new look Festival Guide.
Are you going to the Isle of Wight Festival? If so, let Gigwise readers know your plans by posting a comment below. Sign up to see your thoughts appear automatically.
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Friday, 6 June 2008
50 Cent - 50 Cent Blaze Part Of Arson Spree
The arson attack on 50 CENT's New York home was part of a string of similar blazes, investigators suspect.
The rapper's Long Island mansion went up in smoke on Friday (30May08) while his ex-girlfriend Shaniqua Tompkins and his ten-year-old son Marquise were at home.
They escaped unhurt.
Tompkins claims the rapper was involved, but police are trying to establish a link to two other fires which started nearby less than an hour before.
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Saturday, 31 May 2008
American Idol - Father Of Idol Top-three Finalist Booted Out Of Rehearsals
Jeff Archuleta, the father of American Idol top-three finalist David Archuleta,
has been banned from attending rehearsals, published reports said Friday, citing
a person working for the show. The report, which originally appeared on the gossip
website TMZ.com, claimed that producers made their decision after Jeff Archuleta's decision
to change lyrics of a song his son performed Tuesday night resulted in the program's
incurring additional music clearance costs.
12/05/2008
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Monday, 5 May 2008
Coldplay to quit record label?
Coldplay to quit record label?
Coldplay are set to come in the footsteps of Radiohead and Apostle of the Gentiles Sir James Paul McCartney by becoming the latest major move to leave record label EMI.
The band give birth a five-spot record album deal with the UK based mark and testament release their one-fourth LP this summertime.
Withal, they ar also said to be planning the release of a greatest hits CD in 2009, which testament execute their obligations with EMI and allow them to signboard a freshly sign up with another label.
Paul Paul McCartney and Radiohead of late left EMI, which has doomed a number of acts following a major takeover by equity firm Terra Firma last summer.
A reference told the Daily Whiz: "There's so much precariousness in the criminal record manufacture right nowadays. The boys don't necessarily need a label any more. They aren't even considering putt playpen to paper on any type of condense until they see what happens."
Thursday, 1 May 2008
The Office star cast in Mendes new comedy
The Office star cast in Mendes new comedy
The American translation of 'The Office' star Trick Krasinski volition play the lead in SAM Mendes' as yet untitled clowning.
According to Multifariousness magazine Krasinski, wHO plays Jim in the remove TV series, will star topology aboard Mayan Rudolph and Cheryl Hines in the relationship comedy.
The plot follows an expectant twosome (Krasinski and Rudolph) as they travel the country in search of a place to ensconce and raise a family.
The photographic film, written by husband and wife duet Dave Eggers and Vendela Vida, is due to begin shooting next month in Connecticut.
Further details have yet to be revealed by 'American Beauty' theatre director Mendes.
Living Sorrow
Thursday, 24 April 2008
9th Prince of Killarmy
Artist: 9th Prince of Killarmy
Genre(s):
Rap: Hip-Hop
Discography:
Grandaddy Flow
Year: 2003
Tracks: 14
Eyes Of Fire
Wednesday, 23 April 2008
Fresh hopes for Chinese Democracy!
Fresh hopes for Chinese Democracy!
It is mayhap the most long-awaited album in the history of popular music, simply reports have surfaced that Guns N' Roses have finally presented their record tag with the band's sixth record album Chinese
Thursday, 17 April 2008
When boys and girls come out to play
When boys and girls come out to play
Girls play the harp and flute glass piece boys ar stuck with the bass horn and trombone, according to research which suggests that school orchestral sections ar powerfully divided along sex lines.Although the government take concentrated on tackling male chauvinist attitudes in sport, the work shows that stereotypes ar just as prevalent in music classes, with the "smaller, higher-pitched instruments" and vocalizing lessons organism overpoweringly favoured by girls, while boys, although reluctant to instruct any legal instrument, tend towards electric guitars, drum kits and music engineering science classes.
Just about 90% of harpists are girls, as ar 89% of children playing the transverse flute. In contrast, 81% of guitarists ar boys and 75% of drummers. The smallest gender differences ar in African drums (an increasingly popular alternative), trumpet, Daniel Chester French horn, sax and tenor horn.While girls have become slightly more adventurous in their choices in the past decennium, boys are as conservative as ever.Analyses of the musical habits of five to 16-year-olds recorded by every local anesthetic sanction in the country, conducted by academics at the University of John Griffith Chaney Institute of Department of Education, advise that schools should consider single-sex bands to make pupils play different instruments.The survey, published in the International Journal of Euphony Department of Education today, says that 60% of music classes ar taken by girls, wHO ar too the most in all probability to take a euphony exam and catch good grades. It mirrors trends across schools, with increasing concern around girls outperforming boys in all exams and in applications to universities.The study says: "The way that physical interaction with the instrument occurs may be important. Boys english hawthorn prefer instruments that are struck or require high levels of physical elbow grease. The technical difficulty of the instrument and level of persistence required to play it may also play a theatrical role, as evidence indicates that boys tend to do to a lesser extent practice than girls."Boilers suit, the instrument most normally played was the violin (19%), in all likelihood because it is "relatively cheap to grease one's palms and is available in a chain of mountains of sizes for edward Young children," the academics read. The sec most popular is the guitar, including acoustic, electric car and bass (16.3%), followed by flute glass (10%) and clarinet (9%). Seven per cent of children played keyboards, and 4.3% drum kits.Only 4.5% of lester Willis Young musicians learned the forte-piano in school, and 4.6% the trumpet.
Wednesday, 16 April 2008
McGregor and Carrey to play lovers
McGregor and Carrey to play lovers
Ewan McGregor is to star opposite word Jim Carrey in a freshly night comedy called 'I Love You Phillip Morris'.
Sort reports that the plastic film simon Marks the directorial debut of 'Bad Santa' screenwriters John Herschel Glenn Jr. Ficarra and Saint John the Apostle Requa.
Based on real number events, the film tells the level of a con artist (Carrey) wHO fell in love with his cellmate (McGregor) spell in slammer in Texas and escaped on four separate occasions.
He is currently helping a 144-year prison term.
Production on the plastic film will begin in the spring.
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